Yervoy 50mg/10ml Injection Solution (Ipilimumab)


Yervoy 50mg injection contains (ipilimumab) which is now available in Pakistan at Online Pharmacy. The price range of a Yervoy 50mg Injection is Rs. 33,000/- to Rs 37,000/-.

Product Description

Brand: Yervoy
Packet Size: 1 Vial
Active ingredient: Ipilimumab
Manufacturer: Bristol Myers Squibb
Treatment: Blood and bone cancer

Additional Details

Additional Details

Uses of the Yervoy 50mg Injection

Yervoy (ipilimumab) 50mg injection is a prescription medication used to fight several types of cancer by increasing the power of your immune system. Here’s a breakdown of its primary uses.

Melanoma: The main application of Yervoy is for treating unresectable or metastatic melanoma. This refers to an aggressive form of skin cancer that has either grown too large or spread to other parts of the body.

Advanced Cancers: In some cases, Yervoy might be used in combination with other medications to treat advanced stages of various cancers. These can include:

  • Non-small cell lung cancer (NSCLC)
  • Kidney cancer (renal cell carcinoma)
  • Liver cancer (hepatocellular carcinoma)
  • Mesothelioma (cancer of the lining of some organs)
  • Esophageal cancer

How Does Yervoy Tablet Work?

Yervoy works by targeting a protein called CTLA-4, which normally acts as a brake on the immune system. By blocking CTLA-4, Yervoy allows the immune system to become more active and better able to identify and destroy cancer cells.

Normally, your immune system that usually prevents it from overreacting and attacking healthy tissues. One such “brake” protein is called CTLA-4.

Yervoy acts as a CTLA-4 inhibitor. It binds to the CTLA-4 protein on T cells (immune cells), effectively taking the brakes off the immune system. By blocking CTLA-4, Yervoy allows T cells to become more activated. These activated T cells can then recognize and attack cancer cells more effectively. This activation of the immune system can lead to inflammation in the body as the immune system ramps up its fight against cancer.

How Should You Take Yervoy 50mg Injection?

Yervoy is delivered through an intravenous (IV) line, meaning it’s injected directly into your vein.

It’s typically given as a series of infusions, with each dose spaced out over a specific timeframe. For example, it might be given every 3 weeks for a set number of cycles. Your doctor will determine the most appropriate dosage and schedule for your specific case.

The recommended dosage of Yervoy (ipilimumab) 50mg injection has different dosages for the different types of cancer.

For Unresectable or Metastatic Melanoma: The recommended dosage of Yervoy is 3 mg/kg administered intravenously over 30 minutes every 3 weeks, for a maximum of 4 doses.

For Adjuvant Treatment of Melanoma: The recommended dosage is 10 mg/kg administered intravenously over 90 minutes every 3 weeks for up to 4 doses, followed by 10 mg/kg every 12 weeks for up to 3 years.

Warnings and Precautions

Warnings and Precautions

It’s important to be aware of some warnings and precautions before starting treatment. Here’s a breakdown of key points to consider.

Serious Immune-Mediated Reactions:

Yervoy can trigger severe immune-mediated adverse reactions. These reactions involve your immune system attacking healthy tissues throughout your body.

Some of the most common potential reactions include:

  • Enterocolitis (inflammation of the intestines)
  • Hepatitis (inflammation of the liver)
  • Dermatitis (skin rash)
  • Neuropathy (nerve damage)
  • Pneumonitis (inflammation of the lungs)
  • Endocrine problems (affecting hormone production)

Other Warnings and Precautions:

Pre-existing Medical Conditions: Disclose any pre-existing medical conditions to your doctor, especially autoimmune diseases or severe infections. Yervoy may not be suitable in certain cases.

Pregnancy and Breastfeeding: Yervoy can harm an unborn baby. Discuss birth control options with your doctor before starting treatment. Avoid breastfeeding while on Yervoy and for some time after discontinuation.

Weakened Immune System: Yervoy can further weaken your immune system, making you more susceptible to infections. Be cautious around people who are sick and practice good hygiene.

Vaccinations: Live vaccines are not recommended while on Yervoy due to the potential for serious infections. Discuss vaccination needs with your doctor before starting treatment.

Possible Side Effects of Yervoy Injection

Possible Side Effects of Yervoy Injection

here are the key possible side effects that may be experienced with Yervoy (ipilimumab) injection:

Common Side Effects:

  • Fatigue
  • Diarrhea
  • Pruritus (itching)
  • Rash
  • Decreased appetite
  • Nausea
  • Fever
  • Cough
  • Shortness of breath
  • Vomiting
  • Constipation
  • Muscle/joint pain
  • Headache
  • Dizziness
  • Insomnia

Serious Side Effects:

  • Severe or ongoing diarrhea, and severe stomach pain.
  • Fever, swollen glands, body aches.
  • New or worsening skin rash, itching, blistering.
  • Chest pain, irregular heartbeats.
  • Severe muscle weakness, and ongoing muscle/joint pain.
  • Numbness or tingling in hands/feet.
  • Vision problems, eye pain/redness.
  • New or worsening cough, chest pain, shortness of breath.
  • Little or no urination, swelling, or blood in urine.
  • Right upper stomach pain, tiredness, bruising/bleeding, dark urine, jaundice
  • Frequent/unusual headaches, lack of energy, dizziness, mood changes, increased thirst/urination.
  • Confusion, memory problems, and seizures.

Can We Use Other Medicines with Yervoy Injection?

Combination Therapy:

Yervoy can be used alone or in combination with other cancer medications, such as Opdivo (nivolumab).

When used in combination, the dosages of each medication are adjusted accordingly.

The combination of Yervoy and Opdivo is approved for treating certain types of cancer, like melanoma, non-small cell lung cancer, and mesothelioma

Can Alcohol Drinker Take Yervoy Injection?

No, it is generally not recommended for patients taking Yervoy (ipilimumab) injections to consume alcohol. Drinking alcohol during Yervoy treatment may increase your risk of side effects like nausea, vomiting, and fatigue.

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