What is a Sutent 50mg Tablets?

Sutent 50mg Tablets contain the active ingredient sunitinib malate, which is a multi-kinase inhibitor used primarily for the treatment of certain types of cancer .

Can I Buy Sutent 50mg Tablets Online in Pakistan?

Yes, you can buy Sutent 50mg Tablets from Online Pharmacy, which is a reliable provider of wellness medicines in Pakistan offering 24/7 delivery service.

How long do cancer patients live with SUTENT?

The survival duration for cancer patients treated with Sutent (sunitinib malate) varies based on the type of cancer and individual patient factors. Renal Cell Carcinoma (RCC): Patients treated with Sutent have shown a median progression-free survival of approximately 11 months, compared to 5 months for those receiving interferon α (IFNα). Gastrointestinal Stromal Tumors (GIST): Sutent has been shown to delay tumor progression by about 21 weeks, with a median progression-free survival of 24.1 weeks compared to 6 weeks for placebo. Pancreatic Neuroendocrine Tumors ( pNET ): The median progression-free survival for patients with pNET treated with Sutent is around 10.2 months, compared to 5.4 months with placebo. Adjuvant Treatment of RCC: In high-risk patients after nephrectomy, Sutent has demonstrated a median disease-free survival of approximately 6.8 years, significantly longer than the placebo group.

How effective is Sutent Tablet?

SUTENT (sunitinib) has shown promising effectiveness in treating certain types of cancers. It has been approved by the U.S. Food and Drug Administration (FDA) for the following indications: Advanced renal cell carcinoma (RCC): Studies have shown that SUTENT can improve survival rates in patients with advanced RCC. Gastrointestinal stromal tumors (GISTs): SUTENT has been shown to be effective in slowing the growth of GISTs and improving progression-free survival. Pancreatic neuroendocrine tumors (PNETs): SUTENT has been shown to reduce tumor growth and improve progression-free survival in patients with PNETs.

How long does it take SUTENT to start working?

Sutent (sunitinib malate) begins to work after the first dose , but patients typically won't feel its effects immediately . The drug acts by inhibiting the growth of cancer cells and blocking the formation of new blood vessels that tumors need to grow.

Is SUTENT a chemotherapy?

No, SUTENT is not a chemotherapy drug.

When is the best time to take SUTENT?

The best time to take Sutent (sunitinib malate) is typically once daily, and it is advisable to take it around the same time each day. This consistency helps maintain stable levels of the medication in your body, enhancing its effectiveness.

Does SUTENT cause bleeding?

Yes, SUTENT can increase the risk of bleeding. This is because it can affect blood clotting. If you notice any unusual bleeding or bruising while taking SUTENT, it's important to inform your healthcare provider.

Does sunitinib cause weight gain?

No, sunitinib typically doesn't cause weight gain. In fact, it's more common for people taking sunitinib to experience weight loss due to side effects like nausea, vomiting, and loss of appetite.

Can SUTENT cause fever?

Yes, SUTENT can cause fever. This is a common side effect of the medication. If you experience fever while taking SUTENT, it's important to monitor it and inform your healthcare provider if it becomes severe or persistent.

What foods should I avoid while taking SUTENT?

While taking Sutent (sunitinib malate), it is advisable to avoid certain foods like Grapefruit and Grapefruit Juice, Alcohol and avoid heavy, greasy, or spicy foods. Instead, opt for bland foods that are easier on the stomach.

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Sutent 50mg Tablets (Sunitinib)

₨220,000.00

Sutent 50mg tablets contains Sunitinib, which is now available in Pakistan at Online Pharmacy. The price range of this is Rs.180,000/-. to Rs.230,000/-.

Product Description

Brand: Sutent
Packet Size: 14 tablets
Active ingredient: Sunitinib
Manufacturer: Pfizer
Treatment: Kidney Cancer

Category: Imported Medicines

Additional Details

Uses of the Sutent 50mg Tablets

Gastrointestinal Stromal Tumor (GIST):

Indicated for adult patients with unresectable or metastatic GIST after disease progression on imatinib mesylate or in cases where the patient cannot tolerate imatinib.

Advanced Renal Cell Carcinoma (RCC):

Approved for the treatment of adult patients with advanced or metastatic RCC.

Adjuvant Treatment of Renal Cell Carcinoma:

Used as an adjuvant therapy in adult patients at high risk of recurrence following nephrectomy (surgical removal of a kidney).

Pancreatic Neuroendocrine Tumors (pNET):

Indicated for the treatment of progressive, well-differentiated pNET in adults with unresectable locally advanced or metastatic disease.

How Does Sutent 50mg Tablet Work?

Sunitinib (Sutent 50mg Tablets) works by targeting and inhibiting specific proteins involved in the growth and development of cancer cells.

Here’s a breakdown of its mechanism of action:

Tyrosine Kinase Inhibition: Sunitinib is a tyrosine kinase inhibitor. Tyrosine kinases are enzymes that play a crucial role in cell signaling, promoting cell growth and survival.

Targeted Protein Blockage: Sunitinib specifically targets and blocks multiple receptor tyrosine kinases, including vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs).

Tumor Growth Inhibition: By inhibiting these receptors, Sunitinib disrupts the signaling pathways that support the growth and survival of cancer cells. This can lead to:

Reduced blood vessel growth: Sunitinib can inhibit the formation of new blood vessels (angiogenesis), which are essential for tumor growth and metastasis.

Cancer cell death: Sunitinib can induce apoptosis, or programmed cell death, in cancer cells.

Tumor shrinkage: Over time, Sunitinib can cause tumors to shrink or stop growing.

How Should You Take Sutent 50mg Tablet?

To take Sutent (sunitinib malate) 50mg Tablets correctly, follow these guidelines:

Sutent can be taken with or without food. However, it’s advisable to maintain a consistent routine regarding meals.

Do not crush, chew, or open the capsules. Swallow them whole to ensure proper absorption and effectiveness.

If you miss a dose, take it as soon as you remember, unless it’s less than 12 hours until your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Regular monitoring of blood pressure and liver function may be necessary during treatment cycles to manage potential side effects effectively.

Recommended Dosage of Sutent 50mg Tablets

Gastrointestinal Stromal Tumor (GIST):

Dosage: 50 mg taken orally once daily.

Schedule: Administered for 4 weeks, followed by a 2-week rest period (Schedule 4/2).

Advanced Renal Cell Carcinoma (RCC):

Dosage: 50 mg taken orally once daily.

Schedule: Same as GIST—4 weeks on, 2 weeks off.

Adjuvant Treatment of RCC:

Dosage: 50 mg taken orally once daily.

Schedule: Follow the same 4/2 cycle for a total of nine cycles.

Pancreatic Neuroendocrine Tumors (pNET):

Dosage: 37.5 mg taken orally once daily.

Schedule: Administered continuously without a scheduled rest period.

Dose Adjustments

Dosage modifications may be necessary based on individual safety and tolerability, typically in increments or decrements of 12.5 mg.

The maximum dose should not exceed 75 mg for GIST and RCC or be reduced below 25 mg.

Warnings and Precautions of Sutent 50mg Tablets

Sutent (sunitinib malate) 50mg Tablets come with several warnings and precautions that patients and healthcare providers should be aware of. Here are the key points:

Hepatotoxicity:

Sutent can cause severe liver damage, which may be fatal. Regular monitoring of liver function through blood tests is essential. Symptoms of liver problems include:

Loss of appetite
Upper right stomach pain
Itching
Dark urine
Jaundice (yellowing of the skin or eyes).

Cardiovascular Events:

There is a risk of serious cardiovascular issues, including heart failure, heart attack, and cardiomyopathy. Patients should be monitored for symptoms like chest pain, shortness of breath, or unusual fatigue

Thrombotic Microangiopathy (TMA):

Sutent may lead to TMA, which involves blood clots in small blood vessels and can affect organs like the brain and kidneys. Symptoms include:

Fever
Fatigue
Decreased urination
Unusual bruising

Skin Reactions:

Severe skin reactions, including blistering or peeling, can occur. Immediate medical attention is required if symptoms develop.

Gastrointestinal Perforation:

There is a risk of gastrointestinal perforation, which can be life-threatening. Patients should report any severe abdominal pain immediately.

Proteinuria and Kidney Problems:

Patients may develop protein in their urine, leading to kidney issues that could be serious or fatal. Regular monitoring is advised.

Endocrine Effects:

Sutent can affect thyroid function; monitoring thyroid levels is recommended, especially if symptoms arise such as fatigue, weight changes, or mood alterations.

Allergic Reactions:

Although rare, allergic reactions may occur, presenting as skin rash, itching, or more severe symptoms like difficulty breathing and swelling.

Mouth Sores:

Mouth sores are common with Sutent use and can range from mild to severe. Patients should inform their healthcare provider if they develop sores.

Possible Side Effects of Sutent 50mg Tablets

Common Side Effects:

Fatigue: Feeling tired or exhausted

Diarrhea: Loose stools

Nausea and vomiting: Feeling sick to your stomach or throwing up

Loss of appetite: Decreased interest in food

Skin rash: Redness, itching, or bumps on the skin

Hair loss: Thinning or loss of hair

Mouth sores: Painful sores in the mouth

High blood pressure: Elevated blood pressure

Less Common Side Effects:

Weight loss: Loss of weight

Constipation: Difficulty passing stools

Cough: A persistent cough

Shortness of breath: Difficulty breathing

Joint pain: Achy or painful joints

Muscle pain: Soreness or tenderness in the muscles

Headache: Pain or discomfort in the head

Dizziness: Feeling lightheaded or dizzy

Serious Side Effects:

Heart problems: Sunitinib can increase the risk of heart problems, such as heart failure and irregular heartbeat.

Bleeding: Sunitinib can increase the risk of bleeding, especially if you have a bleeding disorder or are taking other medications that can affect blood clotting.

Kidney problems: Sunitinib can damage the kidneys, leading to kidney failure.

Liver problems: Sunitinib can damage the liver, leading to liver failure.

Severe skin reactions: Sunitinib can cause severe skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis.

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