Revolade 50mg 14’s Tablets (Eltrombopag)
₨80,000.00
Revolade contains eltrombopag which is now available in Pakistan at Online Pharmacy. The price range of the Temotaj Capsules is Rs 75,000/- to Rs 85,000/-.
Product Description
Brand: Revolade
Form: Tablets
Strength: 50mg
Size: 14’s Tablets
Active Ingredient: Eltrombopag
Manufacturer: GlaxoSmithKline
Treatment: Chronic Immune/ Bleeding Disorder
Additional Details
Uses of the Revolade 50mg 14’s Tablets
Revolade 50mg 14’s Tablets are primarily used to treat low platelet count due to:
Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP): This is a condition where the immune system mistakenly attacks and destroys platelets, leading to excessive bleeding.
Chronic Hepatitis C Virus (HCV) Infection: In some cases, HCV infection can cause low platelet counts, which can interfere with treatment for the virus. Revolade can help increase platelet levels to allow for effective HCV treatment.
Severe Aplastic Anemia: This is a rare condition where the bone marrow fails to produce enough blood cells, including platelets. Revolade can stimulate platelet production in patients with severe aplastic anemia.
How Does Revolade 50mg Tablet Works?
Revolade, containing the active ingredient eltrombopag, works by mimicking the action of a natural hormone called thrombopoietin (TPO). TPO is responsible for stimulating the production of platelets in the bone marrow.
Here’s a breakdown of its mechanism of action:
TPO Receptor Activation: Eltrombopag binds the thrombopoietin receptor (TPO-R) on the surface of cells in the bone marrow. This binding activates a signaling pathway within the cell.
Megakaryocyte Production: The activated signaling pathway triggers the production of megakaryocytes. These are large cells in the bone marrow that give rise to platelets.
Platelet Production: Megakaryocytes mature and fragment into platelets, which are then released into the bloodstream.
How Should You Take Revolade 50mg Tablet?
To take Revolade 50 mg tablets accurately, follow these guidelines:
Swallow the tablet whole with a full glass of water. Do not chew, crush, or break the tablet.
Empty Stomach: Take the tablet on an empty stomach, either 1 hour before meals or 2 hours after meals.
Do not consume dairy products, antacids, or mineral supplements containing calcium, iron, magnesium, aluminum, selenium, or zinc within 2 hours before or 4 hours after taking Revolade. These substances can interfere with the absorption of the medication.
Daily Routine: It is advisable to take Remolade at the same time each day to help remember your dosage schedule.
Recommended Dosage of Revolade 50mg Tablets
The recommended dosage for Revolade (Eltrombopag) 50 mg tablets varies based on the patient’s condition and ancestry. Here are the key points regarding the dosage:
General Dosage Guidelines
Adults with Immune Thrombocytopenia (ITP): The usual starting dose is 50 mg once daily.
Adults of East/Southeast Asian descent: The recommended starting dose is 25 mg once daily due to different pharmacokinetics in this population.
Special Populations
HCV Patients: The starting dose for adults with hepatitis C-related thrombocytopenia is also 25 mg once daily, regardless of ancestry.
Severe Aplastic Anemia (SAA): For adults with previously treated SAA, the starting dose is 50 mg once daily, while those of East/Southeast Asian origin should start at 25 mg once daily.
Dose Adjustments
After initiating treatment, the dose may be adjusted based on platelet counts:
If platelet counts are below 50,000/µL after at least two weeks, increase the dose by 50 mg, up to a maximum of 150 mg per day.
For patients with platelet counts between 50,000/µL and 150,000/µL, use the lowest effective dose to maintain counts.
If counts exceed 150,000/µL, reduce the dose by 25 mg and monitor closely.
Warnings and Precautions of Revolade 50mg Tablets
It’s Important to be aware of the following warnings and precautions associated with Revolade 50mg tablets:
Warnings:
Blood Clots: Revolade can increase the risk of blood clots, especially in people with certain risk factors like a history of blood clots, immobility, or certain medical conditions.
Liver Problems: Revolade can cause liver damage. It’s important to monitor liver function regularly while taking this medication.
Cataracts: Patients may be at risk for developing cataracts while on Revolade. Regular eye examinations may be recommended.
Precautions:
Pregnancy and Breastfeeding: Revolade can harm an unborn baby. Pregnant women should not take this medication. It’s also unknown if Revolade passes into breast milk. Consult your doctor before breastfeeding while taking Revolade.
Kidney Problems: If you have kidney problems, your doctor may need to adjust your Revolade dose.
Allergic Reactions: If you have an allergy to eltrombopag or any other ingredients in Revolade, do not take this medication.
Bleeding Risks: After discontinuing Revolade, platelet counts will revert to baseline levels within approximately four weeks. This can increase the risk of bleeding symptoms; thus, monitoring is essential.
Possible Side Effects of Revolade 50mg Tablets
Revolade (Eltrombopag) 50 mg tablets can cause a range of side effects, some of which may be serious. Here’s a comprehensive overview of potential side effects associated with this medication:
Common Side Effects
These side effects may affect more than 1 in 10 people:
- Nausea
- Diarrhea
- Headache
- Fatigue
- Muscle pain
- Cough
- Loss of appetite
- Fever
- Rash
- Dizziness
Uncommon Side Effects
These side effects may affect up to 1 in 10 people:
- Thrombosis (blood clots)
- Hepatitis
- Upper respiratory tract infections
- Abdominal pain
- Joint pain and muscle spasm
Rare Side Effects
These may affect up to 1 in 1,000 people:
Thrombotic microangiopathy, which can lead to kidney impairment
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