Xtandi 40mg Tablets (Enzalutamide)


(2 customer reviews)

Xtandi 40mg Tablets contain Enzalutamide which is now available in Pakistan at Online Pharmacy. The price range of Xtandi tablets is Rs. 260,000/-  to Rs. 290,000/-

Product Description

Brand: Xtandi
Packet Size: 112’s Capsules
Active ingredient: Enzalutamide
Manufacturer: Astellas
Treatment: Prostate Cancer

Additional Details

Additional Details

Uses of the Xtandi 40mg Tablets

Here’s a breakdown of its specific uses:

1. Metastatic Hormone-Sensitive Prostate Cancer (mHSPC):

This is prostate cancer that has spread to other parts of the body (metastasized) but still responds to hormone therapy that lowers testosterone (androgen deprivation therapy).
Xtandi is used in combination with androgen deprivation therapy to further improve treatment outcomes.

2. High-Risk Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC):

This refers to prostate cancer that hasn’t spread but is resistant to treatments that lower testosterone (castration-resistant) and shows signs of a high risk of spreading in the future (based on specific factors like PSA levels and bone scans).
Xtandi is used as a single agent in this context to delay the spread of the cancer.

3. Other Potential Uses:

In some cases, Xtandi might be used after chemotherapy for advanced prostate cancer, but this decision should be made in consultation with a healthcare professional.

How Does Xtandi Work?

It works by blocking the action of male hormones (androgens), such as testosterone, which can help to slow the growth and spread of the cancer. Here’s a breakdown of how it works

1. Targeting Androgens: Prostate cancer cells often rely on androgens to grow and divide. Xtandi belongs to a class of drugs called androgen receptor inhibitors. These drugs work by interfering with the way androgens bind to and activate the androgen receptors in cancer cells.

2. Blocking the Signal: When an androgen binds to an androgen receptor, it sends a signal to the cell to grow and divide. Xtandi acts like a blocker, preventing the androgen from binding to the receptor and stopping the growth signal from being transmitted.

3. Slowing Cancer Growth: As a result of blocking the androgen signal, Xtandi can slow the growth of prostate cancer cells and even cause some of them to die. This can help to delay the progression of the cancer and improve overall survival rates.

How Should You Take Xtandi Tablets?

To take Xtandi tablets, follow these instructions:

Xtandi can be taken with or without food.

Swallow the tablets whole; do not chew, dissolve, or open them. Do not cut, crush, or chew the tablets.

Take your prescribed dose once a day, at the same time each day.

If you miss a dose, take only that day’s prescribed dose. Do not double up on your prescribed dose if you miss a day. Resume taking your prescribed dose at the regular time the following day.

When discussing the recommended dosage for Xtandi 40mg tablets, it’s important to keep the information straightforward and accessible. Xtandi is primarily prescribed for individuals battling prostate cancer, and understanding the correct dosage is crucial for effective treatment.

For adults diagnosed with prostate cancer, the usual dosage is 160 mg, which translates to four 40 mg capsules taken orally once a day. This dosage is a general guideline and applies to patients with different stages and types of prostate cancer, including castration-resistant prostate cancer (CRPC) and metastatic castration-sensitive prostate cancer (mCSPC).

If you’re taking Xtandi, there’s an important consideration regarding additional treatments. Patients with CRPC or mCSPC should also be receiving a gonadotropic-releasing hormone (GnRH) analog alongside Xtandi, or they should have undergone a bilateral orchiectomy. This combination of treatments is vital for managing your condition effectively.

For those with non-metastatic castration-sensitive prostate cancer (nmCSPC) who are at a high risk of biochemical recurrence (BCR), Xtandi may be used with or without a GnRH analog. This flexibility in treatment allows healthcare providers to tailor the therapy to individual patient needs.

Furthermore, there’s an opportunity to pause treatment under certain conditions. If you’re receiving Xtandi and your prostate-specific antigen (PSA) becomes undetectable (< 0.2 ng/mL) after 36 weeks of therapy, your doctor might consider suspending the treatment. However, it’s crucial to closely monitor your PSA levels, as treatment should be reinitiated once the PSA increases to ≥ 2.0 ng/mL for those who had a prior radical prostatectomy or ≥ 5.0 ng/mL for patients who underwent prior primary radiation therapy.

We understand that managing prostate cancer is a complex journey, and it’s essential to stay informed about your treatment options. Always consult your healthcare provider to ensure that your treatment plan, including the dosage of Xtandi, is tailored to your specific needs and health status. Remember, the goal is to navigate this path with the most effective and personalized care possible.

Warnings and Precautions of Xtandi Tablets

Warnings and Precautions of Xtandi Tablets


If you have a history of seizures, brain injury, stroke, or brain tumors, it’s crucial to inform your doctor.

Let your doctor know if you’ve had heart disease, high blood pressure, or abnormal levels of fat or cholesterol in your blood (dyslipidemia).

If you’re pregnant or planning to become pregnant, it’s essential to understand that Xtandi can potentially harm your unborn baby or lead to miscarriage. If you’re a male with a partner who can get pregnant, using effective birth control during treatment and for three months after the last dose is necessary. Additionally, it’s important to use a condom during sex with a pregnant partner.

If you’re breastfeeding or planning to breastfeed, consult your doctor, as it’s not known whether Xtandi passes into breast milk.


Before starting enzalutamide (the active ingredient in Xtandi), inform your doctor or pharmacist about any allergies you have or if you’re allergic to any inactive ingredients in the product.

Share your medical history, especially if you have high blood pressure, a history of seizures, risk factors for seizures, heart disease, diabetes, high cholesterol or triglyceride levels, a history of falls, or broken bones.

Since Xtandi may rarely cause seizures, consult your doctor about avoiding activities where sudden loss of consciousness could pose a risk to yourself or others.

Be aware that Xtandi can cause dizziness and combining it with alcohol or marijuana can intensify this effect. Refrain from driving or operating machinery until you’re sure you can do so safely. Limit your alcohol intake, and discuss marijuana use with your doctor.

Before undergoing surgery, inform your doctor or dentist about all the medications you’re taking, including prescription drugs, over-the-counter medications, and herbal products.

Possible Side Effects of Xtandi Tablets

Possible Side Effects of Xtandi Tablets

You may notice some side effects while taking Xtandi tablets. These could include hot flashes, headaches, dizziness, or a decrease in sexual interest or ability. If any of these effects persist or become bothersome, it’s important to inform your doctor or pharmacist promptly.

It’s important to remember that your doctor prescribed this medication because they believe the benefits outweigh the potential risks of side effects. Many people who use this medication do not experience serious side effects.

However, you should contact your doctor immediately if you experience any of the following serious side effects: back pain, numbness, tingling, weakness, or pain in the arms or legs; falls or broken bones; or notice pink or red urine.

Xtandi may also raise your blood pressure. Be sure to check your blood pressure regularly and inform your doctor if you notice high readings.

Seek medical help right away if you experience very serious side effects such as persistent headaches, decreased alertness, seizures, sudden changes in vision, mental or mood changes (such as memory problems or confusion), or signs of a heart attack like chest pain, jaw pain, left arm pain, shortness of breath, or unusual sweating.

Additionally, Xtandi may lower your ability to fight infections, making you more susceptible to serious infections or worsening any existing infection. Notify your doctor immediately if you develop signs of infection such as a persistent sore throat, fever, chills, or cough.

Although rare, a severe allergic reaction to Xtandi is possible. Seek immediate medical attention if you experience symptoms such as a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.

This list doesn’t cover all possible side effects. If you notice any other effects not mentioned here, it’s important to contact your doctor or pharmacist for further guidance.

Can We Use Other Medicines with Xtandi Tablets?

Yes, you can take Xtandi tablets with other medications, but it’s crucial to inform your doctor about every medicine you’re currently using. This includes all prescription drugs, over-the-counter medicines, herbal remedies, and any supplements.

Some drugs that might interact with Xtandi are abiraterone acetate, alfacalcidol, aliskiren, antiarrhythmics, asunaprevir, cobicistat, ergot alkaloids, fentanyl, lurasidone, pimozide, quinidine, medications for seizures, St. John’s wort, tenofovir, among others. Xtandi could also influence how other medicines function, so it’s vital to follow your doctor’s instructions on how to take it correctly. Never alter or stop your prescribed dosage without first discussing it with your doctor.

Can Alcohol Drinker Take Xtandi Tablets?

The interaction between Xtandi and alcohol isn’t fully understood. However, both Xtandi and alcohol are processed by the liver. Drinking excessive alcohol when on Xtandi could overwhelm your liver, hindering its ability to metabolize the medication properly. This can raise the risk of experiencing side effects from Xtandi.

Therefore, it’s important to discuss with your doctor how much alcohol, if any, is safe for you to consume while taking Xtandi. Additionally, since Xtandi can interact with various other medications, it’s crucial to inform your doctor about all the prescription, over the counter, and herbal medications you’re taking, as well as any supplements.

Can You Take Xtandi Tablets If You’re Pregnant?

No, Xtandi tablets should not be used if you’re pregnant. According to the guidelines, Xtandi can harm the fetus due to how it works. As a result, it’s not recommended for women who are, or might become, pregnant while on the medication. If you become pregnant while taking Xtandi, you should be aware of the possible risks to the baby and the chance of losing the pregnancy. It’s important for women who could get pregnant to use reliable birth control while undergoing treatment with Xtandi.

Reviews (2)

2 reviews for Xtandi 40mg Tablets (Enzalutamide)

  1. zubair shiekh

    reliable supplier!!

  2. Maqsood Ahmed

    genuine product

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