What is an Octagam 2.5g Injection?

Octagam 2.5g Injection is a medication that contains human immunoglobulin G (IgG), a type of antibody that helps the immune system fight off infections.

Can I Buy Octagam 2.5g Injection Online in Pakistan?

Yes, you can buy Octagam 2.5g Injection from Online Pharmacy, which is a reliable provider of wellness medicines in Pakistan offering 24/7 delivery service.

Is Octagam a chemo drug?

No, Octagam is not a chemotherapy drug.

How long does an Octagam infusion take?

Start at an infusion rate of 0.5 mg/kg/min (equivalent to 30 mg/kg/hr). If tolerated, increase the rate to 1 mg/kg/min (or 60 mg/kg/hr). If further tolerated, increase to 2 mg/kg/min (or 120 mg/kg/hr). After the initial hour and if no adverse reactions occur, the infusion rate can be maintained at a maximum of 3.33 mg/kg/min (or 200 mg/kg/hr) as tolerated.

Octagam 2.5g Injection is generally considered safe for use. A post-authorization safety analysis indicated that approximately 92% of patients tolerated Octagam without any adverse drug reactions (ADRs). The overall incidence of reported ADRs was about 1.0% across numerous infusions.

What is the new indication of Octagam?

The new indication for Octagam includes its use in the treatment of multifocal motor neuropathy (MMN). This addition expands its application beyond existing indications, which already cover various conditions such as: Primary Immunodeficiency Disorders (PID) : For patients with impaired antibody production. Chronic Immune Thrombocytopenic Purpura (ITP) : To manage low platelet counts. Guillain-Barré Syndrome : To alleviate symptoms during acute phases. Kawasaki Disease : For inflammation of blood vessels in children. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) : To improve neurological function.

Is Octagam a blood product?

Yes, Octagam is a blood product. It's a human immunoglobulin G (IgG) product derived from human plasma. This means it's made from a component of donated blood.

Does Octagam cause weight gain?

No, Octagam does not directly cause weight gain. However, it's important to note that the conditions treated with Octagam , such as primary humoral immunodeficiency (PI) and certain autoimmune diseases, can sometimes lead to weight changes. For example, some people with PI may experience weight loss due to frequent infections or difficulty absorbing nutrients.

Does Octagam have sugar?

Yes, Octagam 2.5g Injection contains maltose, which is a disaccharide sugar derived from corn. Each 50 mL vial of Octagam includes approximately 100 mg of maltose.

Is Octagam FDA approved?

Yes, Octagam is FDA approved. The U.S. Food and Drug Administration (FDA) has approved Octagam for the treatment of primary humoral immunodeficiency (PI) in patients aged 1 year and older. It is also approved for the treatment of Kawasaki disease in children.

Is Octagam compatible with normal saline?

Yes, Octagam 2.5g Injection is compatible with normal saline. The infusion line can be flushed before and after the administration of Octagam using either 0.9% saline or 5% dextrose in water.

Octagam 2.5g/50ml Injection (immunoglobulin G)

₨25,000.00

Octagam 2.5g injection contains human immunoglobulin G (IgG). which is now available in Pakistan at Online Pharmacy. The price range of the Octagam 2.5g injection is Rs.23,000/-. to Rs.27,000/-.

Product Description

Brand: Octagam
Form: Intravenous injection
Packet Size: 50ml vial
Active ingredient: Human immunoglobulin G (IgG)
Manufacturer: Octapharma AG
Treatment: Primary humoral immunodeficiency (PI)

Category: Imported Medicines

Additional Details

Uses of the Octagam 2.5g Injection

Octagam 2.5g Injection is primarily used for the treatment of various medical conditions related to immune deficiencies and autoimmune disorders. Here are the key uses:

Primary Immunodeficiencies

Octagam is indicated for patients with primary immunodeficiency disorders (PID), which include:

X-linked agammaglobulinemia
Congenital agammaglobulinemia
Common variable immunodeficiency
Wiskott-Aldrich syndrome
Severe combined immunodeficiencies

These conditions result in inadequate antibody production, making patients susceptible to infections

Chronic Immune Thrombocytopenic Purpura (ITP)

Octagam is approved for treating chronic ITP, a condition characterized by low platelet counts. It helps increase platelet levels, thereby reducing the risk of bleeding and complications associated with low platelet counts.

Autoimmune Disorders

The injection is also used in the management of several autoimmune disorders, including:

Guillain-Barré Syndrome: A condition that leads to muscle weakness and paralysis.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A neurological disorder affecting the peripheral nerves.

Kawasaki Disease: An inflammatory condition that affects blood vessels in children.

How Does Octagam 2.5g Injection Work?

Octagam 2.5g injection works by providing a concentrated dose of human immunoglobulin G (IgG) antibodies to the body. IgG is a type of antibody that plays a crucial role in the immune system by helping to fight off infections and regulate the immune response.

Here’s a breakdown of how it works:

Antibody Deficiency: In conditions like primary humoral immunodeficiency (PI), the body doesn’t produce enough antibodies on its own. This leaves individuals susceptible to frequent infections.

Antibody Replacement: Octagam 2.5g injection contains a concentrated dose of IgG antibodies derived from human plasma. When administered, these antibodies supplement the body’s own immune response.

Immune System Boost: The additional IgG antibodies provided by Octagam help the immune system to:

Fight infections: Neutralize viruses, bacteria, and other pathogens.

Regulate immune response: Prevent excessive immune reactions that can lead to autoimmune diseases.

How Often Octagam 2.5g is Given?

Octagam 2.5g Injection is typically administered every 3 to 4 weeks for patients with primary humoral immunodeficiencies. The recommended dosage is between 300 to 600 mg/kg body weight (6-12 mL/kg) during each infusion.

The specific frequency and amount may vary based on individual patient needs, clinical response, and monitoring of trough levels. If a patient misses a scheduled dose, it should be given as soon as possible, and treatment should continue as before.

Recommended Dosage of Octagam 2.5g Injection

The recommended dosage of Octagam 2.5g injection can vary depending on the specific condition being treated and the individual patient’s needs. It’s essential to consult with a healthcare professional for personalized dosing instructions.

Primary Humoral Immunodeficiency (PI):

Initial dose: 200-400 mg/kg body weight, administered over 2-5 days.

Maintenance dose: 200-400 mg/kg body weight every 3-4 weeks, adjusted based on antibody levels.

Autoimmune Diseases:

Kawasaki disease: 2 g/kg body weight, administered over 1-2 days.

Guillain-Barré syndrome: 0.4 g/kg body weight daily for 2-3 days, followed by weekly maintenance doses.

Chronic immune thrombocytopenia (ITP): 0.4 g/kg body weight, administered over 1-2 days, followed by weekly or biweekly maintenance doses.

Warnings and Precautions of Octagam 2.5g Injection

Hypersensitivity Reactions

Allergic reactions: Octagam can cause allergic reactions, including anaphylaxis. If you have a history of allergies to blood products, inform your healthcare provider.

Skin reactions: You may experience skin reactions such as hives, itching, or rashes.

Infusion Reactions

Fever: Octagam can cause fever during or after the infusion.
Chills: You may experience chills during the infusion.
Headache: Headache is a common side effect.
Nausea and vomiting: Some individuals may experience nausea or vomiting.
Muscle aches and pains: You may feel muscle aches and pains.

Blood Clotting Risks:

Thrombosis: Octagam can increase the risk of blood clots, especially in individuals with pre-existing risk factors such as heart disease, stroke, or blood clotting disorders.

Kidney Problems

Acute kidney injury: In rare cases, Octagam can cause acute kidney injury. This is more likely in individuals with pre-existing kidney problems or who receive high doses of the medication.

Pregnancy and Breastfeeding

Pregnancy: The safety of Octagam during pregnancy has not been fully established. Discuss the potential risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.

Breastfeeding: It is unknown if Octagam is excreted in breast milk. Consult with your healthcare provider regarding the potential risks and benefits if you are breastfeeding.

Possible Side Effects of Octagam 2.5g Tablet

Octagam 2.5g injection, like any medication, can cause side effects. While most side effects are mild, some can be more serious.

Common Side Effects:

Fever: Feeling feverish or having chills
Headache: Pain or discomfort in the head
Fatigue: Feeling tired or exhausted
Muscle aches and pains: Soreness or tenderness in the muscles
Nausea and vomiting: Feeling sick to your stomach or throwing up
Skin reactions: Rash, itching, or hives
Injection site reactions: Pain, redness, or swelling at the injection site.

Less Common Side Effects:

Back pain: Pain in the back
Dizziness: Feeling lightheaded or dizzy
Insomnia: Difficulty sleeping
Joint pain: Pain in the joints
Chest pain: Discomfort or pain in the chest
Shortness of breath: Difficulty breathing

Serious Side Effects:

Allergic reactions: In rare cases, Octagam can cause severe allergic reactions, including anaphylaxis. Symptoms of anaphylaxis may include difficulty breathing, swelling of the face or throat, rapid heartbeat, and low blood pressure.

Blood clots: Octagam can increase the risk of blood clots, such as deep vein thrombosis (DVT) and pulmonary embolism.

Kidney problems: In rare cases, Octagam can cause acute kidney injury.

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