Adcetris Injection 50mg (Brentuximab Vedotin)


Adcetris contains (Brentuximab vedotin) which is now available in Pakistan at Online Pharmacy. The price of Adcetris Injection is Rs.210,000/- to Rs.250,000/-

Product Description:

Brand: Adcetris
Packet Size: 1’s Injection
Active ingredient: Brentuximab vedotin
Manufacturer: Takeda
Treatment: Cancer

Additional Details

Additional Details

Uses of Adcetris 50mg Injection

Adcetris 50mg injection is used to treat several types of lymphoma, a cancer of the lymphatic system. However, it’s important to understand that it specifically targets cancer cells expressing the CD30 protein. Here’s a breakdown of its approved uses:

Hodgkin Lymphoma:

Untreated Stage 3 or 4: In combination with other chemotherapy drugs like doxorubicin, vinblastine, and dacarbazine, for adults with previously untreated advanced classical Hodgkin lymphoma.
Relapsed or High-Risk Relapse: For adults with Hodgkin lymphoma that has relapsed (come back) after stem cell transplant or other treatments or are thought to have a high risk of relapse.

Anaplastic Large Cell Lymphoma (ALCL):

Untreated Systemic ALCL: In combination with other chemotherapy drugs like cyclophosphamide, doxorubicin, and prednisone, for adults with previously untreated systemic ALCL.
Relapsed or Refractory ALCL: For adults with ALCL who have relapsed or are resistant to other treatments.

Other CD30-expressing Peripheral T-cell Lymphomas (PTCLs):

Previously Untreated: In combination with other chemotherapy drugs, for adults with previously untreated PTCLs like angioimmunoblastic T-cell lymphoma (AITL) and PTCL not otherwise specified (PTCL-NOS) that express CD30.

How Does Adcetris Injection Work?

It works in a targeted way to specifically attack cancer cells, minimizing harm to healthy cells compared to traditional chemotherapy. Here’s a breakdown of how it works:

Adcetris contains a monoclonal antibody, which acts like a precise lock seeking out a specific key found on certain cancer cells. This key is a protein known as CD30, present in some lymphoma cells.

When Adcetris finds and attaches to the CD30 protein, it’s like delivering a hidden weapon inside the cancer cell. This weapon is a powerful drug that interrupts the cancer cell’s ability to grow and divide, eventually causing the cell to die.

How Should You Take Adcetris 50mg Injection?

To take the Adcetris 50mg injection, you should follow these steps under a healthcare professional’s guidance:

We’ll calculate the correct dose for you based on your weight and the prescribed treatment plan. Typically, the starting dose for Adcetris is 1.8 mg/kg, administered once every 3 weeks.

To prepare the injection, we’ll adhere to the manufacturer’s instructions:

Withdraw 50 mg from a single vial using a syringe.
Add the withdrawn content to an infusion bag filled with either 0.9% Sodium Chloride Injection, 5% Dextrose Injection, or Lactated Ringer’s Injection, to achieve a final concentration between 0.4 mg/mL and 1.2 mg/mL.
We’ll gently mix the solution by inverting the bag, making sure not to shake it.
Throughout the preparation process, we’ll employ aseptic techniques to reduce the risk of infection.

The Adcetris solution should be infused immediately through a venous access device, typically over a 30-minute period.

After the infusion, it’s important to dispose of any unused portions and waste materials according to local regulations.

The recommended dosage of the Adcetris 50mg injection varies based on the patient’s medical condition, body weight, and how well they respond to the treatment. Initially, the dose is usually set at 1.8 mg/kg, administered once every three weeks. This dose is given as an intravenous infusion, which should last about 30 minutes. The highest dose that can be given is 180 mg every three weeks, whether used alone or alongside chemotherapy.

Warnings and Precautions Adcetris

Warnings and Precautions Adcetris


Do not use Adcetris if you are currently being treated with the cancer medication bleomycin.
Adcetris can lead to a severe brain infection that may cause disability or death. Immediately contact your doctor if you experience issues with speech, thought, vision, or muscle movement.


Avoid Adcetris if you are allergic to brentuximab vedotin or if you are receiving bleomycin for cancer.
To ensure Adcetris is safe for you, inform your doctor if you have had:
Liver disease
Kidney disease
Peripheral vascular disease, such as Raynaud’s syndrome

Birth Control:
Both men and women should use effective birth control methods to avoid pregnancy while using Adcetris, as it can harm an unborn baby or cause birth defects. Continue using birth control for at least 6 months following your final dose of Adcetris.
If a pregnancy occurs while either the mother or father is using Adcetris, tell your doctor immediately.

Possible Side Effects of Adcetris Injection

Possible Side Effects of Adcetris Injection

Emergency Situations:
If you experience signs of an allergic reaction to Adcetris, such as hives, difficulty breathing, or swelling in your face or throat, or if you have a severe skin reaction that includes fever, sore throat, eye burning, skin pain, or a red or purple skin rash that spreads and blisters, seek emergency medical help immediately.

During or Shortly After Injection:
Some side effects may occur either during the injection or within 24 hours afterwards. If you feel dizzy, nauseated, chilled or feverish, itch, or have trouble breathing, inform your caregiver right away.

Serious Conditions:
Brentuximab vedotin could cause a severe brain infection leading to disability or death. Promptly call your doctor if you encounter speech, thought, vision, or muscle movement issues, which may worsen quickly.

Other Serious Side Effects:
Contact your doctor if you experience any of the following, even months after receiving Adcetris:

Numbness, weakness, burning pain, a tingling sensation, or loss of feeling in your arms or legs.
Sudden chest pain, wheezing, dry cough, or shortness of breath.
Pain or burning sensation when urinating.
High blood sugar symptoms like increased thirst and urination, dry mouth, or fruity breath odor.
Ketoacidosis symptoms, including nausea, vomiting, stomach pain, confusion, drowsiness, or trouble breathing.
Low blood cell counts, indicated by fever, chills, tiredness, mouth or skin sores, easy bruising, unusual bleeding, pale skin, cold extremities, feeling light-headed or short of breath.
Signs of tumor cell breakdown, such as confusion, weakness, muscle cramps, nausea, vomiting, abnormal heart rate, decreased urination, or tingling in your hands and feet or around your mouth.
Pancreatitis is marked by severe upper stomach pain spreading to your back, with nausea and vomiting.
Liver problems, including loss of appetite, upper right side stomach pain, fatigue, dark urine, or yellowing of the skin or eyes.
Severe stomach issues, such as new or worsening stomach pain, severe constipation, bloody or tarry stools, or vomiting material that looks like coffee grounds.

Common Side Effects:
The more common side effects of Adcetris may include numbness or tingling, fever, low blood cell counts, nausea, vomiting, diarrhea, constipation, or feeling tired.

Can We Use Other Medicines with Adcetris 50mg Injection?

Using other medicines with Adcetris 50mg injection can sometimes be unsafe. Different medications might affect the levels of Adcetris in your blood, potentially leading to increased side effects or reducing the effectiveness of the treatments.

Brentuximab vedotin, the active ingredient in Adcetris, can interact with various other substances. This includes prescription medications, over-the-counter drugs, vitamins, and herbal products. It’s important to inform your doctor about all the medicines you are currently taking, as well as any new medications you begin or stop using.

Can Alcohol Drinker Take Adcetris Injection?

Yes, people who are receiving Adcetris injections can drink alcohol. However, consuming alcohol might increase certain side effects like nausea, tiredness, and issues with the liver. If you decide to drink alcohol while on Adcetris, it’s important to talk to your doctor first. They can advise whether it’s safe for you and provide specific guidelines on alcohol use.

Can You Take Adcetris Injection If You’re Pregnant?

No, you should not take Adcetris (brentuximab vedotin) if you’re pregnant, as it can harm the fetus. There haven’t been sufficient studies on Adcetris in pregnant women to ensure its safety. If you are pregnant or planning to become pregnant, it’s important to discuss the potential risks and benefits of using Adcetris with your doctor.

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