What is Eltrombopag?
Eltrombopag is a medication used to treat low platelet counts in certain blood disorders. It works by stimulating your bone marrow to produce more platelets, reducing the risk of bleeding. You might take it if you have conditions like immune thrombocytopenia, chronic hepatitis C-related thrombocytopenia, or severe aplastic anemia. Typically taken as an oral tablet once daily, its dosage depends on your specific condition and medical guidance. While it helps manage symptoms, it isn’t a cure and may have side effects like headaches or liver issues. Always follow your healthcare provider’s instructions, as Eltrombopag requires regular monitoring.
How Does Eltrobopag Work?
Eltrombopag works by mimicking your body’s natural thrombopoietin, a protein that signals your bone marrow to produce platelets. It binds to and activates thrombopoietin receptors, encouraging stem cells to develop into mature platelets. This helps increase platelet counts if you have disorders where your body doesn’t make enough platelets naturally. Unlike treatments that suppress your immune system, Eltrombopag directly targets platelet production. Its effects are dose-dependent, requiring regular blood tests to ensure optimal levels and avoid overproduction.
What are the Side Effects of the Eltrobopag Tablet?
Eltrombopag tablets may cause side effects, which can vary in severity. Common side effects include:
- Nausea
- Headache
- Dizziness
- Fatigue
- Diarrhea
- Loss of appetite
- Muscle or joint pain
Serious side effects may include:
- Liver problems (yellowing of skin or eyes, dark urine, abdominal pain)
- Blood clot risk (swelling, chest pain, trouble breathing)
- Eye problems (blurry vision, cataracts)
- Unusual bruising or bleeding
What are the Warning & Precautions of the Eltrombopag Tablets?
Warnings & Precautions for Eltrombopag Tablets
Liver Problems:
Eltrombopag can increase liver enzyme levels, leading to liver damage.
You should have regular liver function tests.
Contact your doctor if you notice yellowing of the skin/eyes, dark urine, or abdominal pain.
Blood Clot Risk:
Eltrombopag may increase the risk of blood clots, especially in people with certain conditions.
Watch for symptoms like swelling, chest pain, or difficulty breathing.
Eye Problems:
Some people may develop cataracts or vision changes.
Regular eye check-ups are recommended.
Bleeding Risks After Stopping the Medication:
Stopping Eltrombopag suddenly can lower platelet levels, increasing the risk of severe bleeding.
Follow your doctor’s instructions when discontinuing the medication.
Iron Absorption Issues:
Eltrombopag can lower iron levels in your body.
Your doctor may monitor iron levels if needed.
Avoid Certain Foods and Supplements:
Calcium-rich foods (like dairy products) can interfere with absorption.
Take Eltrombopag at least 2 hours before or 4 hours after consuming dairy, antacids, or supplements containing calcium, magnesium, or aluminum.
Use in Pregnancy and Breastfeeding:
The safety of Eltrombopag in pregnancy is not well-established.
If you are pregnant or planning to conceive, consult your doctor.
It is unknown if Eltrombopag passes into breast milk, so discuss breastfeeding with your doctor.
What Foods Should You Avoid When Taking Eltrombopag?
When taking eltrombopag, you should avoid foods or supplements high in calcium, iron, aluminum, magnesium, or zinc within 4 hours of your dose, as they can reduce its effectiveness. This includes dairy products (like milk or yogurt), iron-fortified cereals, red meat, spinach, and antacids containing these minerals. Take eltrombopag on an empty stomach, either 1 hour before or 2 hours after meals, unless your doctor advises otherwise. Always check labels of fortified foods or supplements and consult your healthcare provider for tailored guidance.
How Long Can you take Eltrombopag Tablet for?
The duration of eltrombopag treatment varies based on your condition, how you respond to the medication, and your doctor’s monitoring. For chronic immune thrombocytopenia (ITP), for example, eltrombopag is often used as long-term, maintenance therapy. Clinical studies have shown that patients may take it for several years with a median duration around 2 to 3 years and some cases extending up to 8 years. Your doctor will regularly check your blood counts and liver function and adjust your treatment plan as needed.
What are the Eltrombopag Tablets Available in Pakistan?
Eltrombopag is available in Pakistan under various brand names and formulations. Here are the primary options including revolade, Elbonix, and Elopag. Here are the details for each of them below.
Dosages: Available in 25 mg and 50 mg tablets.
Pack Size: Typically sold in packs of 28 tablets.
Manufacturer: GlaxoSmithKline.
Indications: Used for treating low platelet counts in conditions like chronic immune thrombocytopenia (ITP) and thrombocytopenia related to hepatitis C134.
Elbonix:
Dosage: 50 mg tablets.
Pack Size: Available in packs of 28 tablets.
Indications: Similar to Revolade, it is used for managing chronic ITP, hepatitis C-related thrombocytopenia, and severe aplastic anemia2.
Elopag:
Dosage: 50 mg tablets.
Indications: This brand is also used for treating thrombocytopenia in similar patient populations as Revolade and Elbonix
