Cyramza 500mg/50ml Injection (Ramucirumab)
₨200,000.00
Cyramza injection contains (Ramucirumab) which is now available in Pakistan at Online Pharmacy. The price range of the Cyramza Injection is Rs 180,000/- to Rs 220,000/-.
Product Description
Brand: Cyramza
Packet Size: 1 Vial
Active ingredient: Ramucirumab
Manufacturer: Lilly
Treatment: Gastric Cancer
Additional Details
Uses of the Cyramza 500mg Injection
Cyramza 500mg injection is a prescription medication used in combination with other therapies to treat certain types of advanced cancers.
Stomach cancer: If you have advanced stomach cancer that has progressed after other treatments, Cyramza might be used along with paclitaxel (another chemotherapy medication).
Non-small cell lung cancer (NSCLC): In the initial stage of treatment for a specific type of NSCLC, Cyramza might be combined with erlotinib (another targeted therapy) if your tumor has particular genetic mutations.
Colorectal cancer: For advanced colorectal cancer that has not responded well to other treatments, Cyramza might be used with a specific chemotherapy regimen (FOLFILRI).
Liver cancer (hepatocellular carcinoma): When surgery or other curative options are not suitable for advanced liver cancer, Cyramza might be combined with sorafenib (another targeted therapy medication).
How Does Cyramza 500mg Injection Work?
Cyramza (ramucirumab) 500mg injection targets a specific protein called vascular endothelial growth factor receptor 2 (VEGFR-2). This protein plays a key role in the growth of new blood vessels, which tumors need to survive and expand.
Here’s how Cyramza works in your body:
Blocks VEGFR-2: By attaching to VEGFR-2, Cyramza disrupts its function. This can help to:
- Slow down the growth of tumors
- Reduce the formation of new blood vessels that supply tumors
- Potentially starve tumors of the oxygen and nutrients they need to survive
How Should You Take Cyramza 500mg Injection?
You shouldn’t take Cyramza 500mg injection yourself. It’s a powerful medication administered by a healthcare professional in a clinical setting, typically a hospital or oncology clinic. Here’s how Cyramza is typically given
A doctor, nurse, or other qualified healthcare provider will administer Cyramza through an intravenous (IV) infusion. This means the medication will be injected into a vein through a thin tube (catheter).
Recommended Dosage of Cyramza Injection
The recommended dosage of Cyramza is 8 mg/kg every 2 weeks administered by intravenous infusion over 60 minutes If the first infusion is tolerated, all subsequent Cyramza infusions may be administered over 30 minutes.
For patients with non-small cell lung cancer, the recommended dosage is 10 mg/kg every 2 weeks administered by intravenous infusion over 60 minutes.
Warnings and Precautions
Cyramza (ramucirumab) 500mg injection comes with several warnings and precautions that you should be aware of before starting treatment.
Cyramza can significantly increase your risk of bleeding, including severe and potentially fatal hemorrhages. This risk is even higher if you have certain medical conditions or are taking medications that also increase bleeding risk.
Cyramza can increase the risk of gastrointestinal (GI) perforations, which are holes that develop in the stomach or intestines. This can be a life-threatening complication.
Cyramza can impair wound healing, so it’s important to inform your doctor about any upcoming surgeries before starting treatment. They may recommend delaying Cyramza infusions for a certain period.
Cyramza can increase the risk of ATEs, which are blood clots that can form in arteries and travel to various organs, potentially leading to strokes, heart attacks, or other serious issues.
Cyramza can cause high blood pressure (hypertension). Your doctor will monitor your blood pressure regularly and may prescribe medication to control it if necessary.
Some patients may experience infusion-related reactions during or shortly after receiving Cyramza. These reactions may include symptoms like fever, chills, headache, nausea, vomiting, or rash.
Possible Side Effects of Cyramza 500mg Injection
Cyramza (ramucirumab) 500mg injection can cause a variety of side effects, some more common than others.
Common Side Effects:
High Blood Pressure (Hypertension): Cyramza can increase blood pressure. Your doctor will monitor your pressure and prescribe medication to control it if needed.
Fatigue: Feeling tired or weak is a common side effect of Cyramza.
Headache: Headaches can occur with Cyramza use.
Nausea and Vomiting: These are gastrointestinal side effects that may happen with Cyramza.
Diarrhea: Cyramza can cause diarrhea in some patients.
Abdominal Pain: Stomach pain can be a side effect of Cyramza.
Constipation: Difficulty having bowel movements can occur with Cyramza.
Decreased Appetite: Loss of appetite is a possible side effect.
Infusion-Related Reactions: These may include fever, chills, headache, nausea, vomiting, or rash during or after Cyramza infusion.
Serious Side Effects:
Increased Risk of Bleeding: Cyramza significantly raises your risk of bleeding, including severe or potentially fatal hemorrhages. Be extra careful to avoid injuries and inform your doctor immediately if you experience any bleeding.
Gastrointestinal (GI) Perforations: Cyramza can increase the risk of holes forming in your stomach or intestines (perforations). This is a life-threatening complication.
Impaired Wound Healing: Cyramza can impair wound healing. Inform your doctor about any upcoming surgeries before starting treatment.
Arterial Thromboembolic Events (ATEs): Cyramza can increase the risk of blood clots that can form in arteries and travel to various organs, potentially leading to strokes, heart attacks, or other serious issues.
Proteinuria and Nephrotic Syndrome: Excess protein in the urine and a related kidney disorder can occur with Cyramza use.
Posterior Reversible Encephalopathy Syndrome (PRES): This is a rare neurological condition that can happen with Cyramza.
Thyroid Function Abnormalities: Cyramza can affect your thyroid function.
Can We Use Other Medicines with Cyramza 500mg injection?
There can be potential interactions between Cyramza (ramucirumab) 500mg injection and other medications. Here’s why caution is necessary:
Increased Risk of Side Effects: Certain medications can worsen Cyramza’s side effects, such as bleeding or impaired wound healing.
Decreased Effectiveness: Some medications can interfere with how Cyramza works in your body, potentially reducing its effectiveness.
Can Alcohol Drinker Take Cyramza 500mg Injection?
No, it’s not recommended because alcohol can increase the risk of liver damage and worsen any liver-related side effects of this medicine.
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