Votrient 400 mg Tablets (Pazopanib)

Recommended Dosage of Voltrient 400mg Tablets

You are advised to take a daily dose of 800 mg, which means taking four 200 mg tablets at once, by mouth.

For patients with moderate hepatic impairment (total bilirubin > 1.5 to 3 × ULN and any ALT value), the recommended dose is 200 mg once daily.

For patients taking strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin), the dose should be reduced to 400 mg once daily.

For patients unable to tolerate the initial dose reduction, the dose may be further reduced to 200 mg once daily, and if this is not tolerated, VOTRIENT should be permanently discontinued.

Warnings and Precautions of Voltrient 400mg Tablets

When taking Votrient tablets, it’s crucial for you to be aware of certain warnings and precautions to ensure your safety:

Warnings:

Do not take Votrient if you have severe liver disease. Pazopanib, the active ingredient, can lead to severe or even life-threatening liver issues. We’ll need to perform regular blood tests to monitor your liver function closely.
Immediately contact your doctor if you experience nausea, vomiting, pain in the upper stomach, loss of appetite, fatigue, easy bruising, dark-colored urine, or jaundice (a yellowing of your skin or eyes).

Votrient may reduce the blood cells that help your body fight infections and aid in clotting, increasing your risk of infections or making it easier for you to bleed. If you notice unusual bruising or bleeding, or if you have signs of an infection like fever, chills, or body aches, let your doctor know right away.

Precautions:

Ensure Votrient is safe for you by informing your doctor if you’ve had any of the following:

Liver, heart disease, heart rhythm issues, or long QT syndrome.
High blood pressure.
A history of blood clots or stroke.
Thyroid disorders.
Headaches, seizures, or vision problems.
Any perforation (hole or tear) or fistula (abnormal passageway) in your stomach or intestines.
Stomach or intestinal bleeding; or
Surgery in the last 7 days.
This straightforward guidance is designed to help you understand the precautions necessary for taking Votrient safely.

Possible Side Effects of Voltrient Tablets

If you’re taking Votrient tablets, it’s important to be aware of possible side effects and know when to seek immediate medical attention:

If you experience symptoms of extremely high blood pressure, such as severe chest pain, intense headaches, blurred vision, pounding in your neck or ears, anxiety, difficulty breathing, or feelings of fainting, you should call your doctor or get emergency medical help right away.

Contact your doctor immediately if you have any of the following:

Headaches, confusion, changes in your mental state, vision problems, or seizures.
Sudden chest pain, wheezing, or a dry cough.
Unusual bleeding or bruising.
Any wound or surgical cut that doesn’t heal.
Rapid or pounding heartbeats, fluttering in your chest, or sudden dizziness, feeling like you might faint.
Symptoms of heart problems, including swelling, rapid weight gain, or shortness of breath.
Indications of liver issues, such as nausea, vomiting, pain in the upper stomach, lack of appetite, fatigue, dark urine, or jaundice.
Signs of infection, like fever, runny nose, sore throat, body aches, skin sores, or pain/burning during urination.
Evidence of stomach bleeding, including stomach pain or swelling, bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
Heart attack symptoms, such as chest pain or pressure, pain spreading to your jaw or shoulder, nausea, and sweating.
Signs of a stroke or blood clot, including sudden numbness or weakness, severe headache, slurred speech, vision problems, chest pain, sudden shortness of breath, or pain or a cold sensation in an arm or leg.
Symptoms of tumor cell breakdown, like fatigue, weakness, muscle cramps, nausea, vomiting, diarrhea, irregular heart rate, or tingling in your hands and feet or around your mouth.

Can We Use Other Medicines with Voltrient Tablets?

Yes, but it’s crucial to remember that Votrient (pazopanib) can interact with other medications. We strongly advise you to share a complete list of all the medications you’re currently taking with your healthcare provider. This list should include prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. The reason is that Votrient and other medicines can influence each other, potentially leading to side effects.

Can You Take Voltrient Tablets if You’re Pregnant?

Votrient (pazopanib) could harm an unborn baby, so it’s advised not to use it during pregnancy. If you’re capable of becoming pregnant, we strongly recommend taking steps to prevent pregnancy while on Votrient, using reliable contraception methods. If you find out you’re pregnant while taking Votrient, it’s crucial to understand the potential risks to the fetus. Discussing the potential risks and benefits of Votrient treatment with your healthcare provider is especially important if you’re pregnant or breastfeeding.