What is Zytiga 250mg Tablets?

Zytiga 250 mg tablets are a film‑coated form of the prescription drug Zytiga, whose active ingredient is abiraterone acetate.

Can I Buy Zytiga 250mg Tablets in Pakistan?

Yes, you can buy Zytiga 250 mg tablets from Online Pharma cy, which is a reliable provider of wellness medicines in Pakistan offering 24/7 delivery service.

What Should You Do If You Take an Overdose of Zytiga 250mg Tablets?

If you take an overdose of Zytiga (abiraterone acetate) 250 mg tablets, you should: Stop taking Zytiga immediately. Seek emergency medical help right away or call Poison Control. There is no specific antidote for Zytiga overdose. Medical care will focus on general supportive measures, including: Monitoring and managing heart rhythm abnormalities (arrhythmias). Checking and correcting low potassium levels (hypokalemia). Monitoring for and managing fluid retention and signs of congestive heart failure. Assessing liver function closely, as overdose may worsen hepatotoxicity. Treating any cardiac failure and optimizing cardiac function if needed. Controlling hypertension and other electrolyte imbalances.

Does Zytiga 250mg Tablets Affect Kidney Patients?

Zytiga (abiraterone acetate) 250 mg tablets can be used in patients with kidney impairment, including those with end-stage renal disease (ESRD) on dialysis, without dose adjustment. No dose adjustment is necessary for patients with renal impairment, including those on hemodialysis. Pharmacokinetic studies show that systemic exposure to abiraterone does not increase in patients with ESRD on dialysis compared to those with normal kidney function.

Does Zytiga 250mg Tablets Affect Liver Patients?

Zytiga (abiraterone acetate) 250 mg tablets can significantly affect liver function and must be used with caution in patients with liver disease. Zytiga has been associated with marked increases in liver enzymes (ALT and AST), sometimes reaching 5 times or more the upper limit of normal, typically within the first 3 months of treatment. About 6% of patients in clinical trials experienced grade 3-4 liver enzyme elevations, and approximately 1.1% discontinued treatment due to liver toxicity.

What happens when you stop taking Zytiga 250mg Tablets?

When you stop taking Zytiga 250mg Tablets (abiraterone acetate) without medical supervision, it can lead to disease progression and a return or worsening of prostate cancer symptoms, especially if the cancer had been responding to the treatment. Cancer Progression Zytiga works by reducing androgen (male hormone) production, which fuels the growth of prostate cancer. Stopping the medication allows androgens to rise again, potentially accelerating tumor growth. Return of Symptoms You may experience a recurrence of symptoms such as bone pain, urinary problems, fatigue, or elevated PSA levels. Loss of Therapeutic Control The effectiveness of the treatment may decline if you stop and then try to restart it later, as resistance can develop. Hormonal Imbalance Zytiga alters hormone levels. Discontinuation can cause your hormone levels to shift again, potentially leading to side effects or imbalances (e.g., high blood pressure, fluid retention).

When is the Best Time to Take Zytiga 250mg Tablets?

Zytiga (abiraterone acetate) 250 mg tablets should be taken once daily on an empty stomach. Do not eat food for at least 2 hours before taking Zytiga and for at least 1 hour after taking Zytiga. Taking it with food can significantly increase the absorption of the medicine, leading to more side effects.

Zytiga 250mg Tablets (Abiraterone Acetate)

₨35,000.00

Zytiga 250mg tablets contains abiraterone acetate which is now available in Pakistan at Online Pharmacy. The price range of the Zytiga tablets is Rs 30,000/– to Rs 45,000/-.

Product Description

Brand: Zytiga
Form: Tablets
Packet Size: 60 Tablets
Active ingredient: Abiraterone Acetate
Manufacturer: Janssen Pharmaceuticals
Treatment: Prostate Cancer

Category: Imported Medicines

Additional Details

Uses of the Zytiga 250mg Tablets

Zytiga 250mg is primarily used to treat prostate cancer that has spread to other parts of the body (metastatic prostate cancer). Specifically, it is prescribed for:

Metastatic castration-resistant prostate cancer (mCRPC):
This is prostate cancer that continues to grow even when the amount of testosterone in the body is reduced to very low levels.

Metastatic high-risk castration-sensitive prostate cancer (mCSPC):
This is an earlier stage of metastatic prostate cancer where hormone therapy can still slow the disease.

How Does Zytiga 250mg Tablets Work?

Zytiga 250mg (active ingredient: Abiraterone Acetate) works by blocking the production of androgens (male hormones) in the body especially testosterone, which fuels the growth of prostate cancer cells.

Here’s how it works step-by-step:

Inhibition of the CYP17 Enzyme:
Zytiga targets an enzyme called CYP17A1, which is crucial in producing androgens in the adrenal glands, testes, and even in the tumor itself.

Reduction in Testosterone Levels:
By inhibiting this enzyme, Zytiga significantly reduces the body’s overall testosterone production, even in places where standard hormone therapies cannot reach.

Slowing Cancer Growth:
With lower testosterone levels, prostate cancer cells are deprived of the hormone they need to grow, which slows or stops the progression of the disease.

Combined with Prednisone:
Zytiga is given with prednisone (a corticosteroid) to help prevent side effects caused by the drop in cortisol levels, which can occur due to CYP17 inhibition.

How Should You Take Zytiga 250mg Tablets?

Take Zytiga once daily as a single dose with water, swallowing tablets whole do not crush, chew, or split them.

Always take Zytiga on an empty stomach:

No food for at least 2 hours before and 1 hour after dosing. Food significantly raises drug absorption and can increase side effects.

Recommended Dosage of Zytiga 250mg Tablets

The recommended dosage of Zytiga (abiraterone acetate) 250 mg tablets is 1,000 mg orally once daily, which corresponds to taking two 250 mg tablets or four 250 mg tablets once a day. This dose is administered together with prednisone:

For metastatic castration-resistant prostate cancer (mCRPC), prednisone is given at 5 mg twice daily.

For metastatic high-risk castration-sensitive prostate cancer (mCSPC), prednisone is given at 5 mg once daily.

Patients should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or have undergone bilateral orchiectomy.

Warnings and Precautions of Zytiga 250mg Tablets

The warnings and precautions for Zytiga (abiraterone acetate) 250 mg tablets include the following key points:

Pregnancy and Handling: Zytiga can cause fetal harm and pregnancy loss if administered to pregnant females. Women who are pregnant or may become pregnant should not handle the tablets without protection (e.g., gloves). Males with female partners of reproductive potential should use effective contraception during treatment and for 3 weeks after the last dose.

Hypokalemia, Fluid Retention, and Cardiovascular Risks: Due to mineralocorticoid excess, Zytiga can cause low blood potassium (hypokalemia), fluid retention, hypertension, and cardiovascular adverse reactions. Patients should be monitored for swelling, high blood pressure, irregular heartbeats, and signs of heart problems.

Liver Toxicity: Zytiga can cause severe liver problems, including elevated liver enzymes, which may require dose interruption, modification, or discontinuation. Signs of liver issues include upper right abdominal pain, nausea, vomiting, dark urine, and jaundice. Liver function should be regularly monitored during treatment.

Hypoglycemia: Severe hypoglycemia has been reported, especially in patients with pre-existing diabetes who are taking certain antidiabetic medications. Blood glucose should be monitored, and antidiabetic drug doses adjusted as necessary.

Avoid Food Around Dosing: Zytiga must be taken on an empty stomach no food for at least 2 hours before and 1 hour after dosing to avoid increased drug absorption and risk of side effects

Allergic Reactions: Seek immediate medical attention if signs of allergic reactions occur, such as hives, swelling of face or throat, or difficulty breathing.

Other Precautions: Use caution in patients with a history of heart disease, adrenal insufficiency, liver or kidney disease, and in the elderly. Avoid St. John’s wort and certain drugs that interact with Zytiga.

Possible Side Effects of Zytiga 250mg Tablets

The possible side effects of Zytiga (abiraterone acetate) 250 mg tablets range from common mild effects to serious adverse reactions:

Common Side Effects

Fatigue (tiredness)

Joint pain or swelling

High blood pressure (hypertension)

Nausea and vomiting

Fluid retention causing swelling (edema), especially in legs and feet

Headache

Diarrhea

Flushing (redness or warmth of the skin)

Upper respiratory infections (e.g., cough, sinus infections)

Bladder or urinary tract infections

Low potassium levels (hypokalemia)

Increased thirst and frequent urination

Muscle pain or cramps

Mood changes and nervousness

Bone pain or fractures

Blurred vision

Loss of appetite and weight changes

Lightheadedness or dizziness

Dry mouth

Serious Side Effects (Require Immediate Medical Attention)

Severe liver problems: Elevated liver enzymes, liver toxicity, or liver failure. Symptoms include yellowing of skin/eyes, dark urine, severe nausea or vomiting.

Heart problems: Irregular heartbeat, chest pain, fainting, or palpitations.

Severe fluid retention: Swelling with pitting edema, sudden weight gain, trouble breathing.

Electrolyte disturbances: Especially low potassium, which can cause muscle weakness, irregular heart rhythms.

Adrenal insufficiency: Particularly if prednisone is stopped abruptly or during stress/infection.

Seizures

Severe allergic reactions: Rash, swelling of face/throat, difficulty breathing.

Urinary tract and kidney problems: Painful urination, bloody or cloudy urine, decreased urine output.

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