Temotaj 20mg 5’s Capsules (Temozolomide)
₨10,000.00
Temotaj contains Temozolomide which is now available in Pakistan at Online Pharmacy. The price range of the Temotaj 20mg capsules is Rs 5,000/- to Rs 12,000/-.
Product Description
Brand: Temotaj
Form: Capsules
Strength: 20mg
Size: 5’s Capsules
Active Ingredient: Temozolomide
Manufacturer: Sartaj Pharma PVT LTD
Treatment: Brain Cancer
Additional Details
Uses of the Temotaj 20mg Capsules
Temotaj 20mg Capsules (Temozolomide) are primarily used for the treatment of certain types of brain cancer. Its specific uses include.
Adjuvant treatment of newly diagnosed anaplastic astrocytoma: This involves administering Temozolomide along with radiotherapy, followed by maintenance therapy to reduce the risk of the cancer recurring.
Treatment of refractory anaplastic astrocytoma: This is used to treat patients whose anaplastic astrocytoma has progressed despite previous treatment with nitrosourea and procarbazine hydrochloride.
How Does Temotaj 20mg Capsule Works?
Temotaj 20mg Capsules (Temozolomide) work by damaging the DNA of cancer cells, preventing them from replicating and growing.
Here’s a breakdown of its mechanism of action:
Conversion to Active Form: Temozolomide itself is not active. It needs to be converted into its active form, which is a compound called MTIC (methyltriazenoimidazole carboxamide).
This conversion occurs within the body, particularly in tumor cells.
DNA Damage: MTIC enters the cancer cells and reacts with DNA, specifically targeting the O6-guanine site. This alkylation process disrupts the DNA structure, leading to cell death.
Cancer Cell Death: The damaged DNA prevents cancer cells from dividing and repairing themselves. This ultimately leads to their death.
Tumor Shrinkage and Control: As cancer cells die, the tumor may shrink or stop growing. This can help control the disease and improve patient outcomes.
How Should You Take Temotaj 20mg Capsule?
Here are some general guidelines on how to take this medication:
Swallowing the Capsule: Swallow the capsule whole with a glass of water. Do not chew, crush, or dissolve the capsule.
Timing of Intake: Your doctor may recommend taking Temotaj on an empty stomach, typically at least one hour before breakfast. However, the specific timing may vary, so follow your doctor’s instructions carefully.
Treatment Schedule: The treatment schedule for Temozolomide often involves taking the medication for a certain number of days each month, followed by a period of rest. Your doctor will provide you with a detailed treatment plan, including the dosage and duration of each cycle.
Cycle Duration: Each treatment cycle typically lasts 28 days. Follow your healthcare provider’s instructions regarding the number of cycles and any dose adjustments based on your response to treatment and side effects.
Recommended Dosage of Temotaj 20mg Temozolomide
The recommended dosage of Temotaj 20mg Capsules (Temozolomide) will be determined by your doctor based on your individual condition and treatment plan. However, here are some general guidelines:
For newly diagnosed anaplastic astrocytoma
Initial treatment: 75 mg/m² per day for 42-49 days, given concomitantly with radiotherapy.
Maintenance therapy: 150 mg/m² per day for 5 days of each 28-day cycle, for up to 6 cycles.
For refractory anaplastic astrocytoma:
Initial treatment: 150 mg/m² per day for 5 days of each 28-day cycle.
Warnings and Precautions of Temotaj 20mg Capsules
Temotaj (temozolomide) 20 mg Capsules come with several warnings and precautions that patients and healthcare providers should consider before use.
Warnings
Myelosuppression: This can lead to low blood cell counts, increasing the risk of infection, bleeding, and anemia.
Hypersensitivity Reactions: Allergic reactions to Temozolomide are rare but can be serious.
Secondary Malignancies: Long-term use of Temozolomide may increase the risk of developing other types of cancer.
Pneumocystis Pneumonia (PCP): This is a serious lung infection that can occur in people with weakened immune systems.
Hepatotoxicity: Temozolomide can cause liver damage, leading to elevated liver enzymes.
Fetal Harm: Temozolomide can harm an unborn baby. Women of childbearing age should use effective birth control during treatment and for a certain period after treatment.
Precautions:
Elderly Patients: Elderly patients may be more sensitive to the side effects of Temozolomide, particularly bone marrow suppression. Close monitoring of blood counts is essential.
Drug Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs and herbal supplements, as they may interact with Temozolomide.
Nausea and Vomiting: Anti-nausea medications can help manage these common side effects.
Monitoring Requirements: Regular blood tests are crucial to monitor blood cell counts and liver function during treatment.
Infusion Administration: If administered intravenously, it’s important to follow the prescribed infusion rate to minimize side effects.
Possible Side Effects of Temotaj 20mg Capsules
Temotaj (temozolomide) 20 mg Capsules can cause a range of side effects, which vary in frequency and severity. Here are the possible side effects associated with Temotaj.
Common Side Effects (affecting more than 10% of patients)
- Nausea: A frequent feeling of sickness.
- Vomiting: The act of expelling stomach contents.
- Constipation: Difficulty in passing stools.
- Loss of Appetite: Reduced desire to eat.
- Alopecia: Hair loss
- Headache: Pain or discomfort in the head.
- Fatigue: Generalized tiredness or weakness.
- Convulsions: Seizures or fits.
- Rash: Skin reactions, which may vary in severity.
Uncommon Side Effects
- Neutropenia: Low levels of neutrophils, increasing infection risk.
- Thrombocytopenia: Low platelet count, leading to increased bleeding risk.
- Lymphopenia: Low lymphocyte levels, affecting immune response.
Serious Side Effects
Some side effects are recorded so infrequently that their frequency is not known:
- Myelosuppression
- Secondary Malignancies
- Pneumocystis Pneumonia (PCP)
- Hepatotoxicity
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