Do not store Kreon 10000 above 25°C and always keep it in the original container. Once opened, do not store it above 25°C and make sure to use it within 6 months. It’s important to keep the container tightly closed. The enzymes in Kreon 10000 are natural products, and their effectiveness in digesting food diminishes over time. If the container is exposed to warm conditions, like in the glove compartment of a car, the decrease in digestive activity happens more quickly.