Xolair (omalizumab) is not likely to lead to noticeable liver damage, as there haven’t been any reports of liver injury linked to omalizumab treatment. In extensive clinical trials, omalizumab didn’t cause changes in liver enzyme levels in the blood, and the occurrence of most side effects was similar whether patients received Xolair or a placebo. This suggests that Xolair is generally safe for your liver, but we’re here to address any concerns or questions you might have about your treatment.