If you have liver disease, you should be careful when taking Sandimmun Neoral because it contains alcohol, which could exacerbate liver conditions. Additionally, the medication can lead to hepatotoxicity and nephrotoxicity, especially at high doses. If you’re living with liver disease, your healthcare provider should closely monitor you for any signs of liver issues, such as yellowing of the skin or eyes (jaundice), abdominal pain, or dark-colored urine. It’s crucial to inform your healthcare provider about your liver condition before starting Sandimmun Neoral to ensure your treatment is safe and effective.