Yes, Sandimmun Neoral can impact individuals with kidney conditions. The medication’s active ingredient, cyclosporine, can lead to nephrotoxicity (kidney damage) and hepatotoxicity (liver damage), especially at high blood concentrations in patients with existing renal function impairment. Those with significant liver issues may require adjustments in their dosage to keep blood levels within a therapeutic range that is both safe and effective. For individuals with compromised kidney function, it’s critical to closely monitor their condition and adjust the dosage as necessary to mitigate potential risks.