Xeljanz (tofacitinib) has no or limited effect on the ability to drive or use machines. However, it is always advisable to be cautious until you know how the medication specifically affects you. The medication is typically taken as a pill and is not expected to cause drowsiness or impair one’s ability to drive. If you have any concerns about driving or operating machinery while taking Xeljanz, it is recommended to discuss them with your healthcare provider.