Femara may have a minor impact on your ability to drive and operate machinery. As fatigue and dizziness are known side effects of using Femara, and somnolence (sleepiness) has also been reported, albeit less commonly, you should exercise caution when driving or using machines after taking Femara. If you feel tired, dizzy, or drowsy, it’s important to avoid activities that require your full attention, like driving, for your safety and the safety of others.