The Everlong tablet is used for premature ejaculation (PE) treatment because it helps delay ejaculation and improves your control during sexual activity.
Everlong Tablet Working in Detail
Active Ingredient
Everlong contains dapoxetine, a short-acting selective serotonin reuptake inhibitor (SSRI). Unlike standard SSRIs used for depression, dapoxetine is designed to work quickly and wear off faster, making it suitable for on-demand use before sex.
Mechanism of Action
Dapoxetine increases serotonin levels in your nervous system. Serotonin is a chemical messenger that plays a role in controlling ejaculation. By boosting serotonin activity, Everlong helps you last longer before climax.
Timing of Effect
You usually take the tablet 1 to 3 hours before sexual activity. Its effect lasts for about 4 to 6 hours, giving you more time and confidence during intimacy.
Clinical Effectiveness
Studies show that men using dapoxetine can increase their intravaginal ejaculatory latency time (IELT), the time between penetration and ejaculation, by 2 to 3 times compared with a placebo. This means you gain significantly more control.
Suitability
- Doctors may recommend Everlong if you have:
- Lifelong PE (ejaculation within 1–2 minutes of penetration from your first sexual experiences).
- Acquired PE (developed later in life).
- Psychological distress or relationship issues due to PE.
How Does Everlong (Dapoxetine) Delay Ejaculation at the Brain Level?
Everlong tablet delays ejaculation by changing how your brain controls the ejaculatory reflex through its action on serotonin. Here’s the breakdown:
Role of Serotonin in Ejaculation
In your brain and spinal cord, serotonin (5-HT) is a chemical messenger that helps regulate when ejaculation happens. Higher serotonin activity generally means delayed ejaculation, while lower activity is linked to faster climax.
How Dapoxetine Works
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI). Normally, after serotonin is released between nerve cells, it is quickly reabsorbed (reuptake) and broken down. Dapoxetine blocks this reuptake, which means serotonin stays active for longer in the brain.
Brain Pathways Involved
The key regions affected are:
Medial preoptic area (MPOA): controls sexual behavior and ejaculation reflexes.
Nucleus paragigantocellularis (nPGi): sends inhibitory signals to delay ejaculation.
By enhancing serotonin activity in these pathways, dapoxetine strengthens the brain’s “braking system” on the ejaculatory reflex.
Result in Your Body
With serotonin signals lasting longer:
- The ejaculatory reflex in your spinal cord is suppressed.
- You gain better control over climax timing.
- Your intravaginal ejaculatory latency time (IELT) is extended, often 2–3 times longer compared with no treatment.
Can Everlong be used safely with tadalafil or other ED drugs?
Everlong (dapoxetine) can sometimes be used with tadalafil or other ED drugs, but only under a doctor’s supervision, because there are safety considerations.
Why They Are Combined
Dapoxetine (Everlong): Treats premature ejaculation (PE) by delaying climax.
Tadalafil (Cialis) or other PDE5 inhibitors: Treat erectile dysfunction (ED) by improving blood flow to the penis.
Many men experience both ED and PE, so doctors may prescribe them together for a more complete treatment.
Safety Profile of the Combination
Clinical studies show that dapoxetine combined with tadalafil or sildenafil can be effective and generally well tolerated in men with both PE and ED.
The combination improves erection quality and extends the time before ejaculation.
Possible Risks
While the combination is possible, you should be aware of potential side effects:
Low blood pressure (hypotension): Both medicines affect blood vessels. You may feel dizzy, lightheaded, or faint, especially if you stand up quickly.
Heart-related strain: If you have existing cardiovascular disease, the risk increases.
Additive side effects: Headache, flushing, or upset stomach may be stronger when the two are taken together.
Who Should Be Cautious
Men taking nitrates (for chest pain) or alpha-blockers (for blood pressure or prostate problems) should not combine these drugs.
Men with severe heart disease, uncontrolled blood pressure, or serious liver/kidney problems need extra caution.