Dapoxetine in Everlong helps with premature ejaculation by acting as a short-acting selective serotonin reuptake inhibitor (SSRI). It works by inhibiting the serotonin transporter, which increases serotonin’s action in the central nervous system. This increased serotonin activity delays the ejaculatory reflex by modulating certain brain regions involved in ejaculation, such as the lateral paragigantocellular nucleus (LPGi) in the brain stem.
Specifically, dapoxetine delays ejaculation by increasing the latency of the pudendal motoneuron reflex discharge (a nerve reflex involved in ejaculation) and reducing the neuronal signaling that triggers ejaculation. This results in prolonged intravaginal ejaculatory latency time (IELT), meaning men can last longer before ejaculation.
Clinical studies and animal models show that dapoxetine significantly delays ejaculation when taken prior to sexual activity, making it effective for men diagnosed with premature ejaculation. It is typically taken on demand before anticipated sexual intercourse rather than as a daily medication.
How Does Dapoxetine Compare to Other PE Treatments?
Dapoxetine is a fast-acting, on-demand treatment for premature ejaculation (PE), offering rapid onset and minimal side effects compared to other medications like paroxetine or tadalafil.
Dapoxetine vs Paroxetine
On-Demand Use: Dapoxetine is designed for on-demand use, taken 1–3 hours before sexual activity, whereas paroxetine is typically taken daily.
Side Effect Profile: Dapoxetine has a shorter half-life, leading to fewer sexual side effects like reduced libido or erectile dysfunction compared to paroxetine.
Efficacy: While paroxetine may offer a greater increase in intravaginal ejaculation latency time (IELT), dapoxetine’s rapid onset makes it more suitable for situational use.
Dapoxetine vs Tadalafil
Primary Indication: Dapoxetine is specifically approved for PE, whereas tadalafil is primarily used for erectile dysfunction but has shown some benefit for PE when combined.
Combination Therapy: Combining dapoxetine with tadalafil may offer enhanced results for men experiencing both PE and erectile dysfunction.
Can Dapoxetine Be Used Long Term For Premature Ejaculation?
Dapoxetine is generally considered safe for short-term, on-demand use to treat premature ejaculation (PE), but long-term use should only be done under the supervision of a healthcare provider to ensure safety and minimize potential side effects.
Long-Term Use Considerations:
Safety Profile: While dapoxetine is generally safe when used as prescribed, long-term use has not been extensively studied. Its primary purpose is for situational use, not long-term daily treatment.
Side Effects: Prolonged use of dapoxetine could increase the likelihood of experiencing side effects, such as dizziness, nausea, or headache. These side effects are generally mild but could become more prominent with continuous use.
Dependency or Tolerance: Since dapoxetine affects serotonin levels, there is a potential risk for psychological dependency or reduced efficacy with long-term use, although this is not commonly observed.
Alternative Long-Term Solutions:
For men looking for a long-term solution to premature ejaculation, other treatments may be more suitable. These include:
SSRIs (Selective Serotonin Reuptake Inhibitors): Medications like paroxetine or sertraline are often used for long-term treatment of PE, but they require daily use and may come with sexual side effects.
Topical Anesthetics: Creams or sprays that numb the penis can help delay ejaculation during intercourse, offering a more immediate long-term solution.
Behavioral Therapies: Techniques like the “stop-start” method or “squeeze” technique can help improve control over ejaculation without relying on medication.
Does Dapoxetine Cure Premature Ejaculation Permanently?
No, Dapoxetine does not cure premature ejaculation (PE) permanently. It provides temporary relief by delaying ejaculation during sexual activity, but it does not address the underlying causes of PE, which means it requires ongoing use for effectiveness.
Can I Take Dapoxetine Daily?
Dapoxetine, as found in the Everlong 60mg tablet, is not intended for daily use. It is typically prescribed for on-demand use, taken 1 to 3 hours before sexual activity, to help manage premature ejaculation (PE). Daily use is generally not recommended unless directed by a healthcare provider.
It is designed to be taken on demand, usually 1 to 3 hours before anticipated sexual activity. Clinical studies have shown that daily dosing of dapoxetine is not recommended due to increased risk of side effects and potential withdrawal effects if used continuously.