While taking riluzole (Rilutek), it’s important to avoid certain foods and beverages including high-fat meals, alcohol, Caffeine, Grapefruit and grapefruit juice.
High-Fat Meals: Consuming Rilutek with a high-fat meal can significantly reduce its absorption. Studies show that a high-fat meal can decrease the maximum serum concentration (Cmax) by about 45% and the area under the curve (AUC) by approximately 20%. Therefore, it is recommended to take Rilutek on an empty stomach, at least 1 hour before or 2 hours after meals.
Caffeine: There is a minor interaction between riluzole and caffeine. While it’s not necessary to completely avoid caffeine, you should monitor your intake, as caffeine can potentially affect the metabolism of riluzole.
Alcohol: Although not specified in detail, it’s advisable to limit alcohol consumption while taking Rilutek, as alcohol can exacerbate potential side effects and may impact liver function.
Grapefruit and grapefruit juice: Although not commonly mentioned with riluzole, grapefruit and grapefruit juice can interact with many medications by affecting how they are metabolized in the liver. It’s advisable to consult your doctor before consuming grapefruit products while on riluzole.