Start at an infusion rate of 0.5 mg/kg/min (equivalent to 30 mg/kg/hr). If tolerated, increase the rate to 1 mg/kg/min (or 60 mg/kg/hr). If further tolerated, increase to 2 mg/kg/min (or 120 mg/kg/hr).
After the initial hour and if no adverse reactions occur, the infusion rate can be maintained at a maximum of 3.33 mg/kg/min (or 200 mg/kg/hr) as tolerated.